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==Surrogate markers==
Paul Alper sent a link to the following cartoon, from the [http://statistically-funny.blogspot.com/search?updated-min=2014-01-01T00:00:00-05:00&updated-max=2015-01-01T00:00:00-05:00&max-results=3 Statistically funny] blog.


::[[File:Biomarkers-Unlimited.jpg | 400px]]


The accompanying text says:
==Forsooth==
<blockquote>
There is a lot of controversy about surrogate outcomes - and debates about what's needed to show that an outcome or measure is a [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287814/ valid surrogate] we can rely on. They can lead us to think that a treatment is
[http://www.ncbi.nlm.nih.gov/pubmed/23360719 more effective] than it really is.
<br><br>
Yet a recent investigative report found that cancer drugs are being increasingly approved based only on surrogate outcomes, like "progression-free survival." That measures biomarker activity rather than overall survival (when people died).
</blockquote>


==Expected value in the NFL==
==Quotations==
Mike Olinick sent a link to the following:
“We know that people tend to overestimate the frequency of well-publicized, spectacular
events compared with more commonplace ones; this is a well-understood phenomenon in
the literature of risk assessment and leads to the truism that when statistics plays folklore,
folklore always wins in a rout.”
<div align=right>-- Donald Kennedy (former president of Stanford University), ''Academic Duty'', Harvard University Press, 1997, p.17</div>


:[http://www.nytimes.com/2015/05/20/sports/football/nfl-explores-making-the-2-point-conversion-more-tempting.html N.F.L.explores making the 2-point conversion more tempting]<br>
----
:by Victor Mather, ''New York Times'', 19 May 2015
 
"Using scientific language and measurement doesn’t prevent a researcher from conducting flawed experiments and drawing wrong conclusions — especially when they confirm preconceptions."
 
<div align=right>-- Blaise Agüera y Arcas, Margaret Mitchell and Alexander Todoorov, quoted in: The racist history behind facial recognition, ''New York Times'', 10 July 2019</div>


As football fans know, following a touchdown, the ball is placed at the two-yard line, where a team has the option of either attempting a 1-point kick or a 2-point play from scrimmage. The kick is almost a guaranteed point; last year, the overall success rate was 99.3% (1222 out of 1230). The 2-point option was introduced 20 years ago to add excitement to the game, but teams elect to use this option only about 5% of the time.  The success rate for the 2-point play over this period is 47.5%, compared with 99% for the kick.  An easy expected value calculation gives 0.95 points for the 2-point play compared with 0.99 points for the kick.
==In progress==
[https://www.nytimes.com/2018/11/07/magazine/placebo-effect-medicine.html What if the Placebo Effect Isn’t a Trick?]<br>
by Gary Greenberg, ''New York Times Magazine'', 7 November 2018


As announced [http://www.nfl.com/news/story/0ap3000000493347/article/nfl-moves-extra-point-to-15yard-line-for-2015-season here], the NFL decided to move the kick to the 15-yard line
[https://www.nytimes.com/2019/07/17/opinion/pretrial-ai.html The Problems With Risk Assessment Tools]<br>
by Chelsea Barabas, Karthik Dinakar and Colin Doyle, ''New York Times'', 17 July 2019


'''Discussion'''
==Hurricane Maria deaths==
Laura Kapitula sent the following to the Isolated Statisticians e-mail list:


==Maybe the "hot hand" exists after all==
:[Why counting casualties after a hurricane is so hard]<br>
Kevin Tenenbaum sent a link to the following working paper :
:by Jo Craven McGinty, Wall Street Journal, 7 September 2018


:[http://papers.ssrn.com/sol3/papers.cfm?abstract_id=2627354 Surprised by the gambler’s and hot hand fallacies? A truth in the law of small numbers]<br>
The article is subtitled: Indirect deaths—such as those caused by gaps in medication—can occur months after a storm, complicating tallies
:by Joshua Miller and Adam Sanjurjo, ''Social Science Research Network'', 6 July 2015
Laura noted that
:[https://www.washingtonpost.com/news/fact-checker/wp/2018/06/02/did-4645-people-die-in-hurricane-maria-nope/?utm_term=.0a5e6e48bf11 Did 4,645 people die in Hurricane Maria? Nope.]<br>
:by Glenn Kessler, ''Washington Post'', 1 June 2018


In the abstract we read, "We find a subtle but substantial bias in a standard measure of the conditional dependence of present outcomes on streaks of past outcomes in sequential data. The mechanism is driven by a form of selection bias, which leads to an underestimate of the true conditional probability of a given outcome when conditioning on prior outcomes of the same kind."  The authors give the following simple example to illustrate the bias
The source of the 4645 figure is a [https://www.nejm.org/doi/full/10.1056/NEJMsa1803972 NEJM article]. Point estimate, the 95% confidence interval ran from 793 to 8498.
<blockquote>
Jack takes a coin from his pocket and decides that he will flip it 4 times in a row, writing down the outcome of each flip on a scrap of paper. After he is done flipping, he will look at the flips that immediately followed an outcome of heads, and compute the relative frequency of heads on those flips. Because the coin is fair, Jack of course expects this conditional relative frequency to be equal to the probability of flipping a heads: 0.5. Shockingly, Jack is wrong. If he were to sample 1 million fair coins and flip each coin 4 times, observing the conditional relative frequency for each coin, on average the relative frequency would be approximately 0.4.
</blockquote>


In [http://andrewgelman.com/2015/07/09/hey-guess-what-there-really-is-a-hot-hand/#comments Hey—guess what? There really is a hot hand!] (9 July 2015), Andrew Gelman implements a simple R simulation that verifies this result (thanks to Jeff Witmer at Isostat for providing a link to this blog post).
President Trump has asserted that the actual number is
[https://twitter.com/realDonaldTrump/status/1040217897703026689 6 to 18].
The ''Post'' article notes that Puerto Rican official had asked researchers at George Washington University to do an estimate of the death toll.  That work is not complete.
[https://prstudy.publichealth.gwu.edu/ George Washington University study]


(See also [https://www.causeweb.org/wiki/chance/index.php/Chance_News_101#The_hot_hand.2C_revisited The hot hand revisited] in Chance News 101 for some earlier data analyses asserting evidence for the hot hand phenomenon.)
:[https://fivethirtyeight.com/features/we-still-dont-know-how-many-people-died-because-of-katrina/?ex_cid=538twitter We sttill don’t know how many people died because of Katrina]<br>
:by Carl Bialik, FiveThirtyEight, 26 August 2015
 
----
[https://www.nytimes.com/2018/09/11/climate/hurricane-evacuation-path-forecasts.html These 3 Hurricane Misconceptions Can Be Dangerous. Scientists Want to Clear Them Up.]<br>
[https://journals.ametsoc.org/doi/abs/10.1175/BAMS-88-5-651 Misinterpretations of the “Cone of Uncertainty” in Florida during the 2004 Hurricane Season]<br>
[https://www.nhc.noaa.gov/aboutcone.shtml Definition of the NHC Track Forecast Cone]
----
[https://www.popsci.com/moderate-drinking-benefits-risks Remember when a glass of wine a day was good for you? Here's why that changed.]
''Popular Science'', 10 September 2018
----
[https://www.economist.com/united-states/2018/08/30/googling-the-news Googling the news]<br>
''Economist'', 1 September 2018
 
[https://www.cnbc.com/2018/09/17/google-tests-changes-to-its-search-algorithm-how-search-works.html We sat in on an internal Google meeting where they talked about changing the search algorithm — here's what we learned]
----
[http://www.wyso.org/post/stats-stories-reading-writing-and-risk-literacy Reading , Writing and Risk Literacy]
 
[http://www.riskliteracy.org/]
-----
[https://twitter.com/i/moments/1025000711539572737?cn=ZmxleGlibGVfcmVjc18y&refsrc=email Today is the deadliest day of the year for car wrecks in the U.S.]


==Some math doodles==
==Some math doodles==
<math>P \left({A_1 \cup A_2}\right) = P\left({A_1}\right) + P\left({A_2}\right) -P \left({A_1 \cap A_2}\right)</math>
<math>P \left({A_1 \cup A_2}\right) = P\left({A_1}\right) + P\left({A_2}\right) -P \left({A_1 \cap A_2}\right)</math>


<math>P(E)  = {n \choose k} p^k (1-p)^{ n-k}</math>
<math>\hat{p}(H|H)</math>
<math>\hat{p}(H|HH)</math>


==Accidental insights==
==Accidental insights==
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----
----
==The p-value ban==
http://www.statslife.org.uk/opinion/2114-journal-s-ban-on-null-hypothesis-significance-testing-reactions-from-the-statistical-arena

Latest revision as of 20:58, 17 July 2019


Forsooth

Quotations

“We know that people tend to overestimate the frequency of well-publicized, spectacular events compared with more commonplace ones; this is a well-understood phenomenon in the literature of risk assessment and leads to the truism that when statistics plays folklore, folklore always wins in a rout.”

-- Donald Kennedy (former president of Stanford University), Academic Duty, Harvard University Press, 1997, p.17

"Using scientific language and measurement doesn’t prevent a researcher from conducting flawed experiments and drawing wrong conclusions — especially when they confirm preconceptions."

-- Blaise Agüera y Arcas, Margaret Mitchell and Alexander Todoorov, quoted in: The racist history behind facial recognition, New York Times, 10 July 2019

In progress

What if the Placebo Effect Isn’t a Trick?
by Gary Greenberg, New York Times Magazine, 7 November 2018

The Problems With Risk Assessment Tools
by Chelsea Barabas, Karthik Dinakar and Colin Doyle, New York Times, 17 July 2019

Hurricane Maria deaths

Laura Kapitula sent the following to the Isolated Statisticians e-mail list:

[Why counting casualties after a hurricane is so hard]
by Jo Craven McGinty, Wall Street Journal, 7 September 2018

The article is subtitled: Indirect deaths—such as those caused by gaps in medication—can occur months after a storm, complicating tallies

Laura noted that

Did 4,645 people die in Hurricane Maria? Nope.
by Glenn Kessler, Washington Post, 1 June 2018

The source of the 4645 figure is a NEJM article. Point estimate, the 95% confidence interval ran from 793 to 8498.

President Trump has asserted that the actual number is 6 to 18. The Post article notes that Puerto Rican official had asked researchers at George Washington University to do an estimate of the death toll. That work is not complete. George Washington University study

We sttill don’t know how many people died because of Katrina
by Carl Bialik, FiveThirtyEight, 26 August 2015

These 3 Hurricane Misconceptions Can Be Dangerous. Scientists Want to Clear Them Up.
Misinterpretations of the “Cone of Uncertainty” in Florida during the 2004 Hurricane Season
Definition of the NHC Track Forecast Cone


Remember when a glass of wine a day was good for you? Here's why that changed. Popular Science, 10 September 2018


Googling the news
Economist, 1 September 2018

We sat in on an internal Google meeting where they talked about changing the search algorithm — here's what we learned


Reading , Writing and Risk Literacy

[1]


Today is the deadliest day of the year for car wrecks in the U.S.

Some math doodles

<math>P \left({A_1 \cup A_2}\right) = P\left({A_1}\right) + P\left({A_2}\right) -P \left({A_1 \cap A_2}\right)</math>

<math>P(E) = {n \choose k} p^k (1-p)^{ n-k}</math>

<math>\hat{p}(H|H)</math>

<math>\hat{p}(H|HH)</math>

Accidental insights

My collective understanding of Power Laws would fit beneath the shallow end of the long tail. Curiosity, however, easily fills the fat end. I long have been intrigued by the concept and the surprisingly common appearance of power laws in varied natural, social and organizational dynamics. But, am I just seeing a statistical novelty or is there meaning and utility in Power Law relationships? Here’s a case in point.

While carrying a pair of 10 lb. hand weights one, by chance, slipped from my grasp and fell onto a piece of ceramic tile I had left on the carpeted floor. The fractured tile was inconsequential, meant for the trash.

BrokenTile.jpg

As I stared, slightly annoyed, at the mess, a favorite maxim of the Greek philosopher, Epictetus, came to mind: “On the occasion of every accident that befalls you, turn to yourself and ask what power you have to put it to use.” Could this array of large and small polygons form a Power Law? With curiosity piqued, I collected all the fragments and measured the area of each piece.

Piece Sq. Inches % of Total
1 43.25 31.9%
2 35.25 26.0%
3 23.25 17.2%
4 14.10 10.4%
5 7.10 5.2%
6 4.70 3.5%
7 3.60 2.7%
8 3.03 2.2%
9 0.66 0.5%
10 0.61 0.5%
Montante plot1.png

The data and plot look like a Power Law distribution. The first plot is an exponential fit of percent total area. The second plot is same data on a log normal format. Clue: Ok, data fits a straight line. I found myself again in the shallow end of the knowledge curve. Does the data reflect a Power Law or something else, and if it does what does it reflect? What insights can I gain from this accident? Favorite maxims of Epictetus and Pasteur echoed in my head: “On the occasion of every accident that befalls you, remember to turn to yourself and inquire what power you have to turn it to use” and “Chance favors only the prepared mind.”

Montante plot2.png

My “prepared” mind searched for answers, leading me down varied learning paths. Tapping the power of networks, I dropped a note to Chance News editor Bill Peterson. His quick web search surfaced a story from Nature News on research by Hans Herrmann, et. al. Shattered eggs reveal secrets of explosions. As described there, researchers have found power-law relationships for the fragments produced by shattering a pane of glass or breaking a solid object, such as a stone. Seems there is a science underpinning how things break and explode; potentially useful in Forensic reconstructions. Bill also provided a link to a vignette from CRAN describing a maximum likelihood procedure for fitting a Power Law relationship. I am now learning my way through that.

Submitted by William Montante